In-vitro diffusion study of caffeine from microemulsion gel system containing grape seed oil

Cellulite was identified by the orange-peel appearance of skin surface that presents in 80-90% post-pubertal women. Caffeine and grape seed oil were known can be used as an anti-cellulite agent. Microemulsion systems are could enhance diffusion rate drugs through skin. This study conducted to develop a microemulsion gel containing caffeine determine effect caffeine's vitro profile. prepared using tween 80 surfactant, glycerin cosurfactant, viscolam mac 10 gelling The preparations evaluated organoleptic, pH, viscosity, rheology, spreadability, globule size, thermodynamic stability tests. In tests performed Franz cell. result showed 1 % 5% grapeseed has good physical characteristics with average size 126 ±17 nm. system cumulative release amount synthetic membrane compared system. Drug kinetics from follows Higuchi model.